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The show revolves around two sisters, Jeevika and Manvi, their relationship, and their bottomless affection for each other. Jeevika is the elder, more mature sister. Manvi is bubbly and wants to help everyone, though she often lands in a mess and has to be rescued by Jeevika. Jeevika and Manvi have been together since childhood. They love each other and wish never to be separated. They have lost their parents but live with other members of their extended family at Rishikesh. Jeevika marries Viren Singh Vadhera, a lawyer from Chandigarh, and soon becomes pregnant. Then she learns to her shock that her beloved sister Manvi has blood cancer. Manvi needs a bone marrow donor to get well. Jeevika is the only one whose marrow matches with Manvi’s. So Jeevika and Viren decide to abort their baby and save Manvi’s life. Viren’s younger brother Virat becomes close to Manvi during this period. Manvi and Virat fall in love with each other. When Manvi is well, she and Virat get married.
At this point, a young man named Karan enters the Vadhera family, claiming to be the son of Viren’s aunt Swamini. But it turns out that he has been planted there by Jaiswal, the Vadhera family’s enemy. One day, there is an altercation during which Jeevika fires a gun and Karan dies. First, Virat takes the blame; then, Jeevika confesses to the killing. But finally, Viren discovers and proves in court that Jaiswal has committed the murder. Swamini is still upset over this and visits Jaiswal in prison. He claims that Viren had framed him to save Jeevika. Swamini believes Jaiswal’s lies and confronts Jeevika. But Jeevika reveals the whole truth about Karan’s murder to Swamini. Swamini has a heart attack, and this leads to a tiff between Jeevika and Viren. Jeevika decides to go back to Rishikesh. So Manvi and Virat make an elaborate plan which succeeds in bringing Viren and Jeevika back together.
Virat wants to pursue a career as a professional singer but faces repeated failures. He decides to leave the Vadhera house so that he can make a name for himself without help from his family. This leads to differences between Virat and Viren. However, the rest of the family somehow manages to persuade Virat and Manvi to stay in the outhouse of the Vadhera mansion. Manvi and Jeevika try making plans to reunite both the brothers. Meanwhile, an unknown enemy starts targeting Viren and Jeevika. On the day of Holi, the enemy’s henchmen attack Viren but Virat rescues him. Virat then asks his brother for forgiveness and all the misunderstandings are resolved.
One day, Viren saves a woman named Riya from commiting suicide. He comes to know that she has some psychological problems and decides to help her. Jeevika also agrees that Viren should help Riya. Viren spends time with Riya and her husband Sambhav. Eventually, Riya gets killed and Viren is arrested for her murder. Manvi and Virat help Jeevika in order to prove Viren’s innocence. They learn that a woman named Sheetal has some connection with Sambhav and the murder case. It is revealed that Sheetal was the one who pretended to be Riya in front of Viren. The actual murder victim, Riya, was a woman Viren had never seen. Jeevika, Manvi and Virat lay a trap for Sambhav and Sheetal. Finally, Sheetal tells the truth about how she and Sambhav fell in love and wanted to get married. But Sambhav was already married to Riya. So Sambhav made a plan to kill Riya and put the blame on Viren. After this confession, the police arrest Sambhav and Viren comes out of jail.
The Vadheras are now living very happily, but Jeevika and Manvi find out that their family in Rishikesh is facing problems. They go to Rishikesh and find out that the cause of the problem is their cousin Dabbu’s wife Sweety. Jeevika, Manvi and Dabbu’s grandmother, Beeji, has signed over the house to Sweety. But, unknown to Beeji and the rest of the family, Sweety is planning to sell the house. Jeevika and Manvi make a successful plan to teach Sweety a lesson. The problem is solved and the sisters return to Chandigarh with their husbands.
Soon after, Virat’s friend Vikram has a family crisis. It takes a lot of hassle but soon they resolve the issues. Jeevika finds out that she has disease which happens to make her not conceive baby properly. While they are solving this out in the hospital, Virat has a conversation with his friend and his friend persuades him that Manvi, his wife does not love him and he plans something to see whats really happening. His friend takes him to a club as part of the plan and give him drugs in his drink. He becomes drunk and his friends make him think he has done something bad with the girl. Manvi finds out it was all a joke and tries to sort him out by tricking him. When he finds out, he walks out on the family, angry.